Tottenham announced in a statement: “It is with immense sadness that we announce the passing of Ugo Ehiogu.”
The former defender, capped four times by England, was being treated in hospital after collapsing at the club’s training headquarters in north London on Thursday.
Ehiogu, who starred for Aston Villa and Middlesbrough duing his playing career, has been on Tottenham’s coaching staff since 2014.
Tottenham’s head of coaching and player development John McDermott said: “Words cannot express the shock and sadness that we all feel at the Club.
“Ugo’s immense presence will be irreplaceable. Our heartfelt sympathies go out to his wife Gemma and his family.”
The club’s statement added: “Ugo received immediate treatment after suffering a cardiac arrest at the Training Centre yesterday (Thursday) before being transferred to hospital, where he passed away in the early hours of this morning.”
Ehiogu made over 300 appearances in a nine-year stay with Villa, helping them win the League Cup in 1994 and 1996.
He joined Middlesbrough in 2000, spending seven years there and winning the League Cup again in 2004.
Ehiogu also played for West Bromwich Albion, Leeds, Glasgow Rangers and Sheffield United before retiring in 2009.
Villa reacted to the news on Twitter.
“We are deeply saddened to hear of the death of our former defender Ugo Ehiogu. Our thoughts are with his family at this terribly sad time.”